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The most famous and lethal outbreak was the so-called Spanish flu pandemic (type A influenza, H1N1 subtype), which lasted from 1918 to 1919. Older estimates say it killed 40–50 million people while current estimates say 50 million to 100 million people worldwide were killed. This pandemic has been described as "the greatest medical holocaust in history" and may have killed as many people as the Black Death. This huge death toll was caused by an extremely high infection rate of up to 50% and the extreme severity of the symptoms, suspected to be caused by cytokine storms. Indeed, symptoms in 1918 were so unusual that initially influenza was misdiagnosed as dengue, cholera, or typhoid. One observer wrote, "One of the most striking of the complications was hemorrhage from mucous membranes, especially from the nose, stomach, and intestine. Bleeding from the ears and petechial hemorrhages in the skin also occurred." The majority of deaths were from bacterial pneumonia, a secondary infection caused by influenza, but the virus also killed people directly, causing massive hemorrhages and edema in the lung.
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What If You Get the Flu? But even if you steer clear of sneezers and you wash your hands regularly, you still might get the flu. At the doctor's office, the doctor will ask you how you've been feeling and examine you. He or she might use a long cotton swab to get a sample of the gunk in your nose or throat. Testing this sample in a lab can determine, for sure, that you have the flu. But usually this isn't necessary. Based on your symptoms, your doctor can usually tell if you have the flu, especially during times when a lot of flu is going around your town.
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